Survival of Bone Marrow-Engrafted Mice Subsequent to Protection from Lethal Radiation by WR 2721

For the first time data are presented for animals treated with bone marrow cells after lethal radiation exposure while protected with WR 2721 (the single radioprotective chemical compound with the highest known dose reduction factor). The ${\rm LD}_{50/30}$ (lethal dose to 50% in 30 days) for mice e...

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Bibliographic Details
Published in:Radiation research 1980-04, Vol.82 (1), p.215-219
Main Authors: Kinnamon, Kenneth E., Ketterling, Lyle L., Ledney, G. David, Lorenz, Gregory B., Mioduszewski, Robert J., Stampfli, Herman F.
Format: Article
Language:English
Subjects:
Amifostine - pharmacology
Animals
Bone marrow
Bone marrow cells
Bone Marrow Transplantation
Chemical hazards
Cobalt Radioisotopes
Correspondence
Gamma Rays
Intravenous injections
Lethal Dose 50
Methods
Mice
Organothiophosphorus Compounds - pharmacology
Radiation chemistry
Radiation Dosage
Radiation Injuries - prevention & control
Radiation protection
Radioprotective agents
Time Factors
Transplantation, Isogeneic
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Summary:For the first time data are presented for animals treated with bone marrow cells after lethal radiation exposure while protected with WR 2721 (the single radioprotective chemical compound with the highest known dose reduction factor). The ${\rm LD}_{50/30}$ (lethal dose to 50% in 30 days) for mice exposed to whole-body 60 Co radiation was elevated from 824 ± 8 rad in unprotected and untreated mice to (a) 1181 ± 33 rad in animals which received syngeneic bone marrow cells after exposure, (b) 1342 ± 27 rad in animals which received WR 2721 before radiation exposure, and (c) 1608 ± 33 rad in animals receiving both the radioprotective agent before exposure and bone marrow engraftment after exposure.
ISSN:0033-7587
1938-5404
DOI:10.2307/3575250