Hyperthermic Modulation of X-Ray-Induced Oncogenic Transformation in C3H 10T 1/2 Cells

The C3H 10T 1/2 mouse embryo cell line was used to determine the effect of hyperthermia on the in vitro oncogenic transforming potential of X irradiation. Heat exposures of 15 min at 45°C or 60 min at 43°C yielded no transformation (frequency < 0.3× 10-4). When either of these heat exposures prec...

Full description

Saved in:
Bibliographic Details
Published in:Radiation research 1981-12, Vol.88 (3), p.619-622
Main Authors: Clark, Edward P., Hahn, George M., Little, John B.
Format: Article
Language:English
Subjects:
Cell culture techniques
Cell lines
CHO cells
Correspondence
DNA
Embryonic cells
HeLa cells
Hyperthermia
Irradiation
Solar X rays
Transformed cell line
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The C3H 10T 1/2 mouse embryo cell line was used to determine the effect of hyperthermia on the in vitro oncogenic transforming potential of X irradiation. Heat exposures of 15 min at 45°C or 60 min at 43°C yielded no transformation (frequency < 0.3× 10-4). When either of these heat exposures preceded exposure to 200 rad of X rays, a four- to fivefold increase in the mean transformation frequency occurred over that resulting from X rays alone. These results may have important clinical implications.
ISSN:0033-7587
1938-5404
DOI:10.2307/3575650