Toxic Variability and Radiation Sensitization by Dichlorodiammineplatinum(II) Complexes in Salmonella typhimurium Cells

The oxidative coordination compound cis-dichlorodiammineplatinum(II) (cis-DDP) is again shown to be a hypoxic cell radiation sensitizer. The mechanism of cis-DDP-induced radiation sensitization is complex. Results here indicate that cis-DDP sensitization operates in part through reactive free radica...

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Bibliographic Details
Published in:Radiation research 1984-09, Vol.99 (3), p.596-608
Main Author: Richmond, Robert C.
Format: Article
Language:English
Subjects:
Action of physical and chemical agents on bacteria
Bacteriology
Biological and medical sciences
Cisplatin - pharmacology
Cytotoxicity
Dose-Response Relationship, Radiation
Free radicals
Fundamental and applied biological sciences. Psychology
Hypoxia
Irradiation
Low temperature
Microbiology
Platinum
Radiation dosage
Radiation effects
Radiation-Sensitizing Agents - pharmacology
Salmonella typhimurium
Salmonella typhimurium - drug effects
Salmonella typhimurium - radiation effects
Sensitization
Time Factors
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Summary:The oxidative coordination compound cis-dichlorodiammineplatinum(II) (cis-DDP) is again shown to be a hypoxic cell radiation sensitizer. The mechanism of cis-DDP-induced radiation sensitization is complex. Results here indicate that cis-DDP sensitization operates in part through reactive free radicals, in part through the interactions of radiation-induced reactive Pt(I) intermediates, and in part through the involvement of thermodynamic and kinetic aspects of Pt(II)-DNA binding during irradiation. For the first time, radiation sensitization by trans-DDP is compared with a sensitizing concentration of cis-DDP within the same study. Both analogs are sensitizers, but with significant differences. Further, irradiated hypoxic solutions of cis-DDP are found to be more toxic than unirradiated solutions.
ISSN:0033-7587
1938-5404
DOI:10.2307/3576334