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Toxic Variability and Radiation Sensitization by Dichlorodiammineplatinum(II) Complexes in Salmonella typhimurium Cells
The oxidative coordination compound cis-dichlorodiammineplatinum(II) (cis-DDP) is again shown to be a hypoxic cell radiation sensitizer. The mechanism of cis-DDP-induced radiation sensitization is complex. Results here indicate that cis-DDP sensitization operates in part through reactive free radica...
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| Published in: | Radiation research 1984-09, Vol.99 (3), p.596-608 |
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| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c361t-8a08f9800d2b7d97049075eee1d86220c7f264bc1d5ead8cfde4966d1adeb7283 |
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| container_end_page | 608 |
| container_issue | 3 |
| container_start_page | 596 |
| container_title | Radiation research |
| container_volume | 99 |
| creator | Richmond, Robert C. |
| description | The oxidative coordination compound cis-dichlorodiammineplatinum(II) (cis-DDP) is again shown to be a hypoxic cell radiation sensitizer. The mechanism of cis-DDP-induced radiation sensitization is complex. Results here indicate that cis-DDP sensitization operates in part through reactive free radicals, in part through the interactions of radiation-induced reactive Pt(I) intermediates, and in part through the involvement of thermodynamic and kinetic aspects of Pt(II)-DNA binding during irradiation. For the first time, radiation sensitization by trans-DDP is compared with a sensitizing concentration of cis-DDP within the same study. Both analogs are sensitizers, but with significant differences. Further, irradiated hypoxic solutions of cis-DDP are found to be more toxic than unirradiated solutions. |
| doi_str_mv | 10.2307/3576334 |
| format | article |
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The mechanism of cis-DDP-induced radiation sensitization is complex. Results here indicate that cis-DDP sensitization operates in part through reactive free radicals, in part through the interactions of radiation-induced reactive Pt(I) intermediates, and in part through the involvement of thermodynamic and kinetic aspects of Pt(II)-DNA binding during irradiation. For the first time, radiation sensitization by trans-DDP is compared with a sensitizing concentration of cis-DDP within the same study. Both analogs are sensitizers, but with significant differences. Further, irradiated hypoxic solutions of cis-DDP are found to be more toxic than unirradiated solutions.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3576334</identifier><identifier>PMID: 6382408</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Academic Press, Inc</publisher><subject>Action of physical and chemical agents on bacteria ; Bacteriology ; Biological and medical sciences ; Cisplatin - pharmacology ; Cytotoxicity ; Dose-Response Relationship, Radiation ; Free radicals ; Fundamental and applied biological sciences. Psychology ; Hypoxia ; Irradiation ; Low temperature ; Microbiology ; Platinum ; Radiation dosage ; Radiation effects ; Radiation-Sensitizing Agents - pharmacology ; Salmonella typhimurium ; Salmonella typhimurium - drug effects ; Salmonella typhimurium - radiation effects ; Sensitization ; Time Factors</subject><ispartof>Radiation research, 1984-09, Vol.99 (3), p.596-608</ispartof><rights>Copyright 1984 Academic Press, Inc.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-8a08f9800d2b7d97049075eee1d86220c7f264bc1d5ead8cfde4966d1adeb7283</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3576334$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3576334$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9065752$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6382408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Richmond, Robert C.</creatorcontrib><title>Toxic Variability and Radiation Sensitization by Dichlorodiammineplatinum(II) Complexes in Salmonella typhimurium Cells</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>The oxidative coordination compound cis-dichlorodiammineplatinum(II) (cis-DDP) is again shown to be a hypoxic cell radiation sensitizer. The mechanism of cis-DDP-induced radiation sensitization is complex. Results here indicate that cis-DDP sensitization operates in part through reactive free radicals, in part through the interactions of radiation-induced reactive Pt(I) intermediates, and in part through the involvement of thermodynamic and kinetic aspects of Pt(II)-DNA binding during irradiation. For the first time, radiation sensitization by trans-DDP is compared with a sensitizing concentration of cis-DDP within the same study. Both analogs are sensitizers, but with significant differences. Further, irradiated hypoxic solutions of cis-DDP are found to be more toxic than unirradiated solutions.</description><subject>Action of physical and chemical agents on bacteria</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Cisplatin - pharmacology</subject><subject>Cytotoxicity</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Free radicals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypoxia</subject><subject>Irradiation</subject><subject>Low temperature</subject><subject>Microbiology</subject><subject>Platinum</subject><subject>Radiation dosage</subject><subject>Radiation effects</subject><subject>Radiation-Sensitizing Agents - pharmacology</subject><subject>Salmonella typhimurium</subject><subject>Salmonella typhimurium - drug effects</subject><subject>Salmonella typhimurium - radiation effects</subject><subject>Sensitization</subject><subject>Time Factors</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><recordid>eNp1kF9LwzAUxYMoc07xEwh5ENSHatK0Sfoo9d9gIOj0daRJyjKStiQtrn56KyvzyafLued374EDwDlGtzFB7I6kjBKSHIApzgiP0gQlh2CKECERSzk7BichbNCgMc0mYEIJjxPEp-BrWW-NhJ_CG1EYa9oeikrBN6GMaE1dwXddBdOa750qevhg5NrWvh4A50ylGztYVeeu5_MbmNeusXqrAzTDqbCurrS1ArZ9szau86ZzMB824RQclcIGfTbOGfh4elzmL9Hi9Xme3y8iSShuIy4QLzOOkIoLpjKGkgyxVGuNFadxjCQrY5oUEqtUC8VlqXSSUaqwULpgMSczcLX7K30dgtflqvHGCd-vMFr9NrcamxvIix3ZdIXTas-NVQ3-5eiLIIUtvaikCXssQzRlafyHbUJb-3_TfgD6jIKi</recordid><startdate>198409</startdate><enddate>198409</enddate><creator>Richmond, Robert C.</creator><general>Academic Press, Inc</general><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198409</creationdate><title>Toxic Variability and Radiation Sensitization by Dichlorodiammineplatinum(II) Complexes in Salmonella typhimurium Cells</title><author>Richmond, Robert C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-8a08f9800d2b7d97049075eee1d86220c7f264bc1d5ead8cfde4966d1adeb7283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Action of physical and chemical agents on bacteria</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Cisplatin - pharmacology</topic><topic>Cytotoxicity</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Free radicals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypoxia</topic><topic>Irradiation</topic><topic>Low temperature</topic><topic>Microbiology</topic><topic>Platinum</topic><topic>Radiation dosage</topic><topic>Radiation effects</topic><topic>Radiation-Sensitizing Agents - pharmacology</topic><topic>Salmonella typhimurium</topic><topic>Salmonella typhimurium - drug effects</topic><topic>Salmonella typhimurium - radiation effects</topic><topic>Sensitization</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Richmond, Robert C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Richmond, Robert C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxic Variability and Radiation Sensitization by Dichlorodiammineplatinum(II) Complexes in Salmonella typhimurium Cells</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>1984-09</date><risdate>1984</risdate><volume>99</volume><issue>3</issue><spage>596</spage><epage>608</epage><pages>596-608</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>The oxidative coordination compound cis-dichlorodiammineplatinum(II) (cis-DDP) is again shown to be a hypoxic cell radiation sensitizer. The mechanism of cis-DDP-induced radiation sensitization is complex. Results here indicate that cis-DDP sensitization operates in part through reactive free radicals, in part through the interactions of radiation-induced reactive Pt(I) intermediates, and in part through the involvement of thermodynamic and kinetic aspects of Pt(II)-DNA binding during irradiation. For the first time, radiation sensitization by trans-DDP is compared with a sensitizing concentration of cis-DDP within the same study. Both analogs are sensitizers, but with significant differences. Further, irradiated hypoxic solutions of cis-DDP are found to be more toxic than unirradiated solutions.</abstract><cop>Oak Brook, Il</cop><pub>Academic Press, Inc</pub><pmid>6382408</pmid><doi>10.2307/3576334</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-7587 |
| ispartof | Radiation research, 1984-09, Vol.99 (3), p.596-608 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_crossref_primary_10_2307_3576334 |
| source | JSTOR Archival Journals and Primary Sources Collection |
| subjects | Action of physical and chemical agents on bacteria Bacteriology Biological and medical sciences Cisplatin - pharmacology Cytotoxicity Dose-Response Relationship, Radiation Free radicals Fundamental and applied biological sciences. Psychology Hypoxia Irradiation Low temperature Microbiology Platinum Radiation dosage Radiation effects Radiation-Sensitizing Agents - pharmacology Salmonella typhimurium Salmonella typhimurium - drug effects Salmonella typhimurium - radiation effects Sensitization Time Factors |
| title | Toxic Variability and Radiation Sensitization by Dichlorodiammineplatinum(II) Complexes in Salmonella typhimurium Cells |
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