The Effect of Low Dose Rate on Recovery of Hemopoietic and Stromal Progenitor Cells in γ-Irradiated Mouse Bone Marrow

Long-term recovery of mouse hemopoietic stem cells (CFU-S and CFU-S per colony), granulocyte-macrophage precursor cells (GM-CFC), and stromal colony-forming units (CFU-F) after doses up to 12.5 Gy was almost complete by 1 year when the dose rate was reduced to 0.0005 Gy/min compared to incomplete re...

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Bibliographic Details
Published in:Radiation research 1988-09, Vol.115 (3), p.481-487
Main Authors: Gallini, R., Hendry, J. H., Molineux, G., Testa, N. G.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biological effects of radiation
Bone marrow
Bone Marrow - radiation effects
Bone Marrow Cells
Bone marrow transplantation
Cell Survival
Cesium Radioisotopes
Cobalt Radioisotopes
Dose-Response Relationship, Radiation
Female
Fundamental and applied biological sciences. Psychology
Gamma Rays
Granulocytes - cytology
Granulocytes - radiation effects
Hematopoiesis
Hematopoietic Stem Cells - radiation effects
Ionizing radiations
Irradiation
Macrophages - cytology
Macrophages - radiation effects
Male
Mice
Progenitor cells
Radiation damage
Radiation dosage
Radiotherapy
Solar X rays
Testa
Tissues, organs and organisms biophysics
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Summary:Long-term recovery of mouse hemopoietic stem cells (CFU-S and CFU-S per colony), granulocyte-macrophage precursor cells (GM-CFC), and stromal colony-forming units (CFU-F) after doses up to 12.5 Gy was almost complete by 1 year when the dose rate was reduced to 0.0005 Gy/min compared to incomplete recovery after doses up to only 6.5 Gy given at >0.7 Gy/min. This sparing effect of dose rate on long-term hemopoietic recovery is in contrast to the generally reported lack of dependence on dose rate for acute survival of hemopoietic progenitors after doses up to 5 Gy. The present results are compatible with the hypothesis that good recovery of the stroma should be reflected in the long-term recovery of hemopoiesis.
ISSN:0033-7587
1938-5404
DOI:10.2307/3577297