Hyperparathyroidism among Atomic Bomb Survivors in Hiroshima

To determine the effect of exposure to atomic bomb radiation on the occurrence of hyperparathyroidism, the prevalence was determined among a population of 3,948 atomic bomb survivors and their controls in Hiroshima. The diagnosis of hyperparathyroidism was based upon histopathological findings or th...

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Bibliographic Details
Published in:Radiation research 1992-06, Vol.130 (3), p.372-378
Main Authors: Fujiwara, Saeko, Sposto, Richard, Ezaki, Haruo, Akiba, Suminori, Neriishi, Kazuo, Kodama, Kazunori, Hosoda, Yutaka, Shimaoka, Katsutaro
Format: Article
Language:English
Subjects:
Adenoma
Adolescent
Adult
Age Factors
Atomic bombs
Biological and medical sciences
Child
Child, Preschool
Confidence limits
Female
Fundamental and applied biological sciences. Psychology
Head
Humans
Hyperparathyroidism
Hyperparathyroidism - epidemiology
Hyperparathyroidism - etiology
Infant
Japan - epidemiology
Male
Nuclear Warfare
Radiation dosage
Radiation effects
Radiation Injuries - complications
Radiotherapy
Risk
Sex Factors
Thyroid cancer
Tissues, organs and organisms biophysics
Tumors
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Summary:To determine the effect of exposure to atomic bomb radiation on the occurrence of hyperparathyroidism, the prevalence was determined among a population of 3,948 atomic bomb survivors and their controls in Hiroshima. The diagnosis of hyperparathyroidism was based upon histopathological findings or the presence of consistent hypercalcemia and elevated levels of serum parathyroid hormone. Primary hyperparathyroidism was diagnosed in 19 persons (3 males, 16 females). Females had approximately a threefold higher overall prevalence of hyperparathyroidism than males (P < 0.05). The prevalence rates of hyperparathyroidism increased with radiation dose ($\chi _{1}^{2}=12$, P < 0.001) after adjusting for sex and age at the time of the bombing. The estimated relative risk was 4.1 at 1 Gy (95% confidence limits 1.7 to 14). There was some evidence that the effect of radiation was greater for individuals who were younger at the time of the bombing. In conclusion, exposure to atomic bomb radiation affected the occurrence of hyperparathyroidism, suggesting that doses of radiation lower than those used in radiotherapy may also induce this disorder.
ISSN:0033-7587
1938-5404
DOI:10.2307/3578384