The bcl-2 Oncogene: Apoptosis and Neoplasia

Cloning of the t(14;18) translocation breakpoint resulted in the identification of a new putative oncogene, which mapped to 18q21, termed bcl-2. The t(14;18) resulted in inappropriately high levels of bcl-2 expression in follicular lymphoma. Prospective studies using mice transgenic for a human bcl-...

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Bibliographic Details
Published in:Radiation research 1993-12, Vol.136 (3), p.307-312
Main Authors: McDonnell, Timothy J., Marin, Maria C., Hsu, Brenda, Brisbay, Shawn M., McConnell, Kristina, Tu, Shi-Ming, Campbell, Martin L., Rodriguez-Villanueva, Julio
Format: Article
Language:English
Subjects:
Animals
Apoptosis
B lymphocytes
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Cell death
Cell lines
Epithelial cells
General aspects
Humans
Lymphoma
Medical sciences
Neoplasia
Neoplasms - etiology
Oncogenes
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogenes
Symposium: Apoptosis/Programmed Cell Death
Transgenic animals
Tumors
Citations: Items that cite this one
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Summary:Cloning of the t(14;18) translocation breakpoint resulted in the identification of a new putative oncogene, which mapped to 18q21, termed bcl-2. The t(14;18) resulted in inappropriately high levels of bcl-2 expression in follicular lymphoma. Prospective studies using mice transgenic for a human bcl-2-immunoglobulin minigene, intended to recreate the molecular features of the t(14;18), demonstrated that bcl-2 gene deregulation was oncogenic. Interestingly, overexpression of bcl-2 showed no demonstrable influence on rates of cellular proliferation. Rather, bcl-2 was found to extend cellular viability by blocking apoptosis. Recent studies with other oncogenes and tumor suppressor genes, such as c-myc and p53, have demonstrated that the deregulation of apoptosis may be of general significance in the development of multiple types of cancer and appears to be a critical event during multistep carcinogenesis. The selective induction of apoptosis in tumor cell populations is now being considered in the design of novel therapeutic interventions.
ISSN:0033-7587
1938-5404
DOI:10.2307/3578541