Reduction of Short-Term Radiation Lethality by Biological Response Modifiers Given Alone or in Association with Other Chemical Protectors

The advantages gained by a combined treatment of different chemical protectors on short-term lethality of X-irradiated adult male mice have been studied. The following compounds were given alone or in a mixture of two or three compounds: 16,16-dimethyl PGE2 ( PGE2), cysteine (Cys), glucan, glutathio...

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Bibliographic Details
Published in:Radiation research 1993-09, Vol.135 (3), p.332-337
Main Authors: Maisin, J. R., Albert, C., Henry, A.
Format: Article
Language:English
Subjects:
16,16-Dimethylprostaglandin E2 - therapeutic use
Amifostine - therapeutic use
Animals
Biological and medical sciences
Biological effects of radiation
Cysteine - therapeutic use
Dosage
Drug Therapy, Combination
Endotoxins
Fundamental and applied biological sciences. Psychology
Glucans
Glucans - therapeutic use
Immunologic Factors - therapeutic use
Irradiation
Male
Mice
Mice, Inbred Strains
Mortality
Protectors
Radiation dosage
Radiation Injuries, Experimental - mortality
Radiation Injuries, Experimental - prevention & control
Radioprotection
Serotonin - therapeutic use
Serotonin receptors
Solar X rays
Tissues, organs and organisms biophysics
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Summary:The advantages gained by a combined treatment of different chemical protectors on short-term lethality of X-irradiated adult male mice have been studied. The following compounds were given alone or in a mixture of two or three compounds: 16,16-dimethyl PGE2 ( PGE2), cysteine (Cys), glucan, glutathione (GSH), 5-hydroxytryptamine (5-HT), mercaptoproprionylglycine (MPG), or WR-2721. The survival of mice treated before X irradiation with the optimal dose of each radioprotector given separately shows that WR-2721 and 5-HT yield the best protection with dose reduction factors (DRFs) of 2.2 and 1.7, respectively. Cysteine, glucan, PGE2, MPG, and GSH, with DRFs of 1.4, 1.4, 1.2, 1.1, and 1.1, respectively, are less efficient radioprotectors. When PGE2 was combined with a low dose of WR-2721 (200 mg/kg), the protection increased in a synergistic way. The increase in protection offered by a combination of PGE2 with Cys, glucan, GSH, or 5-HT is less marked and the effect obtained is only additive. A synergistic action is also obtained with a combination of WR-2721 (200 mg/kg) and 5-HT (8 mg/kg) (DRF 2.7).
ISSN:0033-7587
1938-5404
DOI:10.2307/3578872