Chromosome Aberrations after Treatment with Radioactive Iodine for Thyroid Cancer

The study aimed to investigate whether the determination of chromosome aberrations in circulating blood lymphocytes could be useful to assess whole-body exposure from radioactive iodine released accidentally. Ten patients treated with two doses of 1850 MBq of 131 I given 24 h apart for thyroid cance...

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Bibliographic Details
Published in:Radiation research 1994-12, Vol.140 (3), p.429-431
Main Authors: Baugnet-Mahieu, L., Lemaire, M., Léonard, E. D., Léonard, A., Gerber, G. B.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood
Chromosome Aberrations
Chromosomes
Dosage
Endocrinopathies
Humans
Iodine
Iodine Radioisotopes - adverse effects
Iodine Radioisotopes - therapeutic use
Lymphocytes
Lymphocytes - radiation effects
Malignant tumors
Medical sciences
Papillae
Radiation Injuries - pathology
Radiation protection
Radiotherapy
Short Communications
Thyroid cancer
Thyroid Neoplasms - radiotherapy
Thyroid. Thyroid axis (diseases)
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Summary:The study aimed to investigate whether the determination of chromosome aberrations in circulating blood lymphocytes could be useful to assess whole-body exposure from radioactive iodine released accidentally. Ten patients treated with two doses of 1850 MBq of 131 I given 24 h apart for thyroid cancer were studied for chromosome aberrations (dicentrics) in blood samples taken before and at various times after exposure. The increase in the yield of aberrations caused by the exposure to iodine was small but statistically significant. Compared to published values for whole-body doses after such treatment, this increase appears to be somewhat smaller than expected from dose-effect relationships obtained for an acute exposure of lymphocytes in vitro or in vivo, a fact which could be explained by the low dose rate of the 131 I exposure. Thus, in situations where a population was exposed as a result of the release of radioactive iodine, a determination of chromosome aberrations in blood lymphocytes would not appear to be very useful to determine exposure from iodine.
ISSN:0033-7587
1938-5404
DOI:10.2307/3579122