Hypoadrenocorticism in Beagles Exposed to Aerosols of Plutonium-238 Dioxide by Inhalation

Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of ^{238}{\rm PuO}{}_{2}$. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradi...

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Bibliographic Details
Published in:Radiation research 1996-12, Vol.146 (6), p.688-693
Main Authors: Weller, R. E., Buschbom, R. L., Dagle, G. E., Park, J. F., Ragan, H. A., Watson, C. R.
Format: Article
Language:English
Subjects:
Addison disease
Addison Disease - etiology
Administration, Inhalation
Adrenal cortex
Adrenal glands
Adrenal Glands - pathology
Adrenal Glands - radiation effects
Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
Aerosols
Animals
Autoimmune diseases
Autoimmune Diseases - etiology
Autoradiography
Biological and medical sciences
Dogs
Endocrinopathies
Female
Inhalation
Lungs
Lymphocytes
Male
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Plutonium
Plutonium - administration & dosage
Plutonium - toxicity
Radiation dosage
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Summary:Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of ^{238}{\rm PuO}{}_{2}$. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradiographs showed only slight α-particle activity. Although the pathogenesis of adrenal cortical atrophy in these dogs is unclear, there is evidence to suggest an autoimmune disorder linked to damage resulting from α-particle irradiation to the lymphatic system.
ISSN:0033-7587
1938-5404
DOI:10.2307/3579386