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Hypoadrenocorticism in Beagles Exposed to Aerosols of Plutonium-238 Dioxide by Inhalation

Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of ^{238}{\rm PuO}{}_{2}$. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradi...

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Published in:	Radiation research 1996-12, Vol.146 (6), p.688-693
Main Authors:	Weller, R. E., Buschbom, R. L., Dagle, G. E., Park, J. F., Ragan, H. A., Watson, C. R.
Format:	Article
Language:	English
Subjects:	Addison disease Addison Disease - etiology Administration, Inhalation Adrenal cortex Adrenal glands Adrenal Glands - pathology Adrenal Glands - radiation effects Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Aerosols Animals Autoimmune diseases Autoimmune Diseases - etiology Autoradiography Biological and medical sciences Dogs Endocrinopathies Female Inhalation Lungs Lymphocytes Male Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Plutonium Plutonium - administration & dosage Plutonium - toxicity Radiation dosage
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container_issue	6
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container_title	Radiation research
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creator	Weller, R. E. Buschbom, R. L. Dagle, G. E. Park, J. F. Ragan, H. A. Watson, C. R.
description	Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of ^{238}{\rm PuO}{}_{2}$. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradiographs showed only slight α-particle activity. Although the pathogenesis of adrenal cortical atrophy in these dogs is unclear, there is evidence to suggest an autoimmune disorder linked to damage resulting from α-particle irradiation to the lymphatic system.
doi_str_mv	10.2307/3579386
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Although the pathogenesis of adrenal cortical atrophy in these dogs is unclear, there is evidence to suggest an autoimmune disorder linked to damage resulting from α-particle irradiation to the lymphatic system.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3579386</identifier><identifier>PMID: 8955720</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Radiation Research Society</publisher><subject>Addison disease ; Addison Disease - etiology ; Administration, Inhalation ; Adrenal cortex ; Adrenal glands ; Adrenal Glands - pathology ; Adrenal Glands - radiation effects ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Aerosols ; Animals ; Autoimmune diseases ; Autoimmune Diseases - etiology ; Autoradiography ; Biological and medical sciences ; Dogs ; Endocrinopathies ; Female ; Inhalation ; Lungs ; Lymphocytes ; Male ; Medical sciences ; Non tumoral diseases. Target tissue resistance. 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E.</creatorcontrib><creatorcontrib>Buschbom, R. L.</creatorcontrib><creatorcontrib>Dagle, G. E.</creatorcontrib><creatorcontrib>Park, J. F.</creatorcontrib><creatorcontrib>Ragan, H. A.</creatorcontrib><creatorcontrib>Watson, C. R.</creatorcontrib><title>Hypoadrenocorticism in Beagles Exposed to Aerosols of Plutonium-238 Dioxide by Inhalation</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of ^{238}{\rm PuO}{}_{2}$. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradiographs showed only slight α-particle activity. Although the pathogenesis of adrenal cortical atrophy in these dogs is unclear, there is evidence to suggest an autoimmune disorder linked to damage resulting from α-particle irradiation to the lymphatic system.</description><subject>Addison disease</subject><subject>Addison Disease - etiology</subject><subject>Administration, Inhalation</subject><subject>Adrenal cortex</subject><subject>Adrenal glands</subject><subject>Adrenal Glands - pathology</subject><subject>Adrenal Glands - radiation effects</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Aerosols</subject><subject>Animals</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - etiology</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Dogs</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Inhalation</subject><subject>Lungs</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Plutonium</subject><subject>Plutonium - administration & dosage</subject><subject>Plutonium - toxicity</subject><subject>Radiation dosage</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LwzAYh4Moc07xEwg5CJ6qSdMk7XHO6QYDPejBU8lfzWibkrSwfXsrK_Pk6cfL7-F9Xx4ArjG6TwniD4TyguTsBEzxkAnNUHYKpggRknCa83NwEeMWDTNmxQRM8oJSnqIp-FztWy90MI1XPnROuVhD18BHI74qE-Fy1_poNOw8nJvgo68i9Ba-VX3nG9fXSUpy-OT8zmkD5R6um29Ric755hKcWVFFczXmDHw8L98Xq2Tz-rJezDeJIgx1iVCiwJgoqnSuKWWFIHkqJJNEEWkJSw2VUhrNlbaZUchiLrXOOGNGWSxzMgN3h71qeC8GY8s2uFqEfYlR-eumHN0M5M2BbHtZG33kRhlDfzv2IipR2SCaQccRSyniWVb8YdvY-fDvtR-DzneQ</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Weller, R. E.</creator><creator>Buschbom, R. L.</creator><creator>Dagle, G. E.</creator><creator>Park, J. F.</creator><creator>Ragan, H. A.</creator><creator>Watson, C. R.</creator><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19961201</creationdate><title>Hypoadrenocorticism in Beagles Exposed to Aerosols of Plutonium-238 Dioxide by Inhalation</title><author>Weller, R. E. ; Buschbom, R. L. ; Dagle, G. E. ; Park, J. F. ; Ragan, H. A. ; Watson, C. 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Renin-angiotensin system (diseases)</topic><topic>Aerosols</topic><topic>Animals</topic><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - etiology</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Dogs</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Inhalation</topic><topic>Lungs</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Plutonium</topic><topic>Plutonium - administration & dosage</topic><topic>Plutonium - toxicity</topic><topic>Radiation dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weller, R. E.</creatorcontrib><creatorcontrib>Buschbom, R. L.</creatorcontrib><creatorcontrib>Dagle, G. E.</creatorcontrib><creatorcontrib>Park, J. F.</creatorcontrib><creatorcontrib>Ragan, H. A.</creatorcontrib><creatorcontrib>Watson, C. 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R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoadrenocorticism in Beagles Exposed to Aerosols of Plutonium-238 Dioxide by Inhalation</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>146</volume><issue>6</issue><spage>688</spage><epage>693</epage><pages>688-693</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of ^{238}{\rm PuO}{}_{2}$. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradiographs showed only slight α-particle activity. Although the pathogenesis of adrenal cortical atrophy in these dogs is unclear, there is evidence to suggest an autoimmune disorder linked to damage resulting from α-particle irradiation to the lymphatic system.</abstract><cop>Oak Brook, Il</cop><pub>Radiation Research Society</pub><pmid>8955720</pmid><doi>10.2307/3579386</doi><tpages>6</tpages></addata></record>
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subjects	Addison disease Addison Disease - etiology Administration, Inhalation Adrenal cortex Adrenal glands Adrenal Glands - pathology Adrenal Glands - radiation effects Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Aerosols Animals Autoimmune diseases Autoimmune Diseases - etiology Autoradiography Biological and medical sciences Dogs Endocrinopathies Female Inhalation Lungs Lymphocytes Male Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Plutonium Plutonium - administration & dosage Plutonium - toxicity Radiation dosage
title	Hypoadrenocorticism in Beagles Exposed to Aerosols of Plutonium-238 Dioxide by Inhalation
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