The Effect of Low-Dose Irradiation on Proliferation of Mammalian Cells In Vitro

The effect of low doses of γ radiation on proliferation of Raji lymphoma cells and Chinese hamster fibroblasts in vitro has been investigated. It is shown that irradiation in the dose range between 2 and 20 cGy (maximum at 10 cGy) stimulates growth of cultured cells due to the shortening of the lag...

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Bibliographic Details
Published in:Radiation research 1996-09, Vol.146 (3), p.329-332
Main Authors: Yu. N. Korystov, Eliseeva, N. A., Kublik, L. N., Narimanov, A. A.
Format: Article
Language:English
Subjects:
Animals
Burkitt Lymphoma
Cell culture techniques
Cell Division - radiation effects
Cell growth
Cell Line
Clone Cells
Cobalt Radioisotopes
Cricetinae
Cricetulus
Cultured cells
Dose-Response Relationship, Radiation
Doubling time
Fibroblasts
Gamma Rays
Humans
Ionizing radiation
Irradiation
Kinetics
Lymphoma
Radiation dosage
Tumor Cells, Cultured
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Summary:The effect of low doses of γ radiation on proliferation of Raji lymphoma cells and Chinese hamster fibroblasts in vitro has been investigated. It is shown that irradiation in the dose range between 2 and 20 cGy (maximum at 10 cGy) stimulates growth of cultured cells due to the shortening of the lag phase of cell growth, with the duration of the doubling time being unchanged. Preirradiation of growth medium in this dose range also stimulates cell proliferation, though to a lesser extent than irradiation of cells and the medium does. The stimulatory effect manifests itself in an increase in the cell number as well as in the size and number of colonies.
ISSN:0033-7587
1938-5404
DOI:10.2307/3579464