Cellular Effects of Individual High-Linear Energy Transfer Particles and Implications for Tissue Response at Low Doses

The energy deposition patterns produced by the radiation environment in space can be quite different from those in conventional radiation environments. Furthermore, conventional radiation biological experiments, using randomly distributed particle tracks, cannot access some variables which may be im...

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Bibliographic Details
Published in:Radiation research 1997-11, Vol.148 (5), p.S108-S114
Main Authors: Braby, Leslie A., Brooks, A. L., Metting, N. F.
Format: Article
Language:English
Subjects:
Alpha Particles
Animal cells
Animals
Biological and medical sciences
Cell communication
Cell lines
Cell nucleus
Cell physiology
Cells, Cultured - radiation effects
CHO cells
Chromosome Aberrations
Chromosomes - radiation effects
DNA damage
DNA Damage - radiation effects
Dose-Response Relationship, Radiation
Effects of physical and chemical agents
Fundamental and applied biological sciences. Psychology
Gamma Rays
Humans
Irradiation
Life Sciences (General)
Linear Energy Transfer
Methods
Micronucleus Tests
Molecular and cellular biology
Radiation damage
Space Flight
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Summary:The energy deposition patterns produced by the radiation environment in space can be quite different from those in conventional radiation environments. Furthermore, conventional radiation biological experiments, using randomly distributed particle tracks, cannot access some variables which may be important in determining the health effects of irradiation. Controlled microbeam irradiation provides the means to investigate the effects and unique energy deposition patterns and cell environment for a variety of end points.
ISSN:0033-7587
1938-5404
DOI:10.2307/3579724