The Vanishing Twin Syndrome: Two cases of extreme malformations associated with vanished twins

• Published in: Pediatric and developmental pathology 2016-06, Article 16-01-1763-CR.1
• Main Authors: Shinnick, Julia K, Khoshnam, Nasim, Archer, Sydney R, Quigley, Philip C, Robinson, Mark, Keene, Sarah, Santore, Matthew T, Hill, Sarah J, Patel, Binita, Shehata, Bahig
• Format: Article
• Language: English
• ISSN: 1093-5266; 1615-5742
• DOI: 10.2350/16-01-1763-CR.1

Two cases of devastating fetal malformations associated with vanished monochorionic twins were identified upon review of pathology files. A 35 year-old G1P0 woman and 36 year-old G3P1 woman were both diagnosed with an intrauterine twin gestation via transvaginal ultrasound at 10 weeks. The spectrum of fetal anomalies ranged from omphalocele, bilateral upper extremity and unilateral lower extremity hypoplasia, to craniofacial malformation with diaphragmatic hernia. On histopathologic examination, the placentas demonstrated vascular anastomoses between the surviving co-twin and the "vanished" fetal sac. We propose anastomotic placental vasculature as a contributing factor to the observed fetal malformations. Additionally, genetic or teratogenic factors may have been attributed to the demise of the first twin and the anomalies seen in the other twin. While such instances are rare, they are important to consider when counseling patients regarding outcomes associated with a monochorionic vanished twin.