Recombinant adeno-associated viruses as a gene delivery vehicle for the use in molecular medicine

Viral mechanisms for the delivery of genetic material are widely used in molecular medicine. Recombinant adeno-associated viruses (rAAV) represent a promising tool for in vivo gene delivery. The review considers nosological spectrum, molecular mechanisms, the choice of drug administration route depe...

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Bibliographic Details
Published in:Bulletin of RSMU 2021-09 (2021(5))
Main Authors: Usman, NYu, Rebrikov, DV
Format: Article
Language:English
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Summary:Viral mechanisms for the delivery of genetic material are widely used in molecular medicine. Recombinant adeno-associated viruses (rAAV) represent a promising tool for in vivo gene delivery. The review considers nosological spectrum, molecular mechanisms, the choice of drug administration route depending on target structures, the choice of serotype, and the methods of active ingredient manufacturing for rAAV-mediated gene therapy.
ISSN:2500-1094
2542-1204
DOI:10.24075/brsmu.2021.051