Potential of non-traditional cell cultures for production of biotherapeutic proteins

Production of biotherapeutic drugs in mammalian cells, recombinant proteins in particular, may be handicapped by the limitations imposed on the cultures by metabolic burden. An alternative solution is to produce proteins in cells of other animals (e.g., Sf9, S2 and High Five insect cell lines, Caeno...

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Bibliographic Details
Published in:Bulletin of RSMU 2024-06 (2024(3))
Main Authors: Dobronos, MA, Osipova, ZM, Myshkina, NM
Format: Article
Language:English
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Summary:Production of biotherapeutic drugs in mammalian cells, recombinant proteins in particular, may be handicapped by the limitations imposed on the cultures by metabolic burden. An alternative solution is to produce proteins in cells of other animals (e.g., Sf9, S2 and High Five insect cell lines, Caenorhabditis elegans and Schistosoma mansoni cell line) or orthogonal cell systems, including plant-based. In our opinion, non-traditional cell cultures may become promising tool for production of affordable and effective biotherapeutic drugs.
ISSN:2500-1094
2542-1204
DOI:10.24075/brsmu.2024.022