Pcl/Chitosan Blended Nanofibrous Tubes Made by Dual Syringe Electrospinning

3D tubular scaffolds made from Poly-(Ɛ-caprolactone) (PCL)/chitosan (CS) nanofibres are very promising candidate as vascular grafts in the field of tissue engineering. In this work, the fabrication of PCL/CS-blended nanofibrous tubes with small diameters by electrospinning from separate PCL and CS s...

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Bibliographic Details
Published in:AUTEX Research Journal 2015-01, Vol.15 (1), p.54-59
Main Authors: Hild, Martin, Fayez Al Rez, Mohammed, Aibibu, Dilbar, Toskas, Georgios, Cheng, Tong, Laourine, Ezzedine, Cherif, Chokri
Format: Article
Language:English
Subjects:
Chitosan
Electrospinning
Nanofibrous Tubes
PCL
Poly-(£-caprolactone)
Polymer blend
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Summary:3D tubular scaffolds made from Poly-(Ɛ-caprolactone) (PCL)/chitosan (CS) nanofibres are very promising candidate as vascular grafts in the field of tissue engineering. In this work, the fabrication of PCL/CS-blended nanofibrous tubes with small diameters by electrospinning from separate PCL and CS solutions is studied. The influence of different CS solutions (CS/polyethylene glycol (PEO)/glacial acetic acid (AcOH), CS/trifluoroacetic acid (TFA), CS/ AcOH) on fibre formation and producibility of nanofibrous tubes is investigated. Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) is used to verify the presence of CS in the blended samples. Tensile testing and pore size measurements are done to underline the good prerequisites of the fabricated blended PCL/ CS nanofibrous tubes as potential scaffolds for vascular grafts. Tubes fabricated from the combination of PCL and CS dissolved in AcOH possesses properties, which are favourable for future cell culture studies.
ISSN:2300-0929
2300-0929
DOI:10.2478/aut-2015-0016