Effects of in Utero and Lactational Exposure to Bisphenol A on Somatic Growth and Anogenital Distance in F1 Rat Offspring

Bisphenol A (BPA), a xenoestrogen, has been reported to mimic the actions of estrogen or to affect the endocrine glands in vivo and in vitro. In this study, we examined whether in utero and lactational exposure to BPA altered the somatic growth and anogenital distance (AGD) of F1 offspring (1, 3, an...

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Bibliographic Details
Published in:Industrial Health 2002, Vol.40(4), pp.375-381
Main Authors: KOBAYASHI, Kenichi, MIYAGAWA, Muneyuki, WANG, Rui-Sheng, SEKIGUCHI, Soichiro, SUDA, Megumi, HONMA, Takeshi
Format: Article
Language:English
Subjects:
Anal Canal - abnormalities
Animals
Anogenital distance
Benzhydryl Compounds
Bisphenol A
Body weight
Body Weight - drug effects
F1 offspring
Female
Genitalia - abnormalities
Lactation
Male
Maternal Exposure
Phenols - administration & dosage
Phenols - toxicity
Pregnancy
Rat
Rats
Rats, Sprague-Dawley
Reproductive toxicity
Teratogens - toxicity
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Summary:Bisphenol A (BPA), a xenoestrogen, has been reported to mimic the actions of estrogen or to affect the endocrine glands in vivo and in vitro. In this study, we examined whether in utero and lactational exposure to BPA altered the somatic growth and anogenital distance (AGD) of F1 offspring (1, 3, and 9 weeks of age) in vivo in rats. Dams were orally administered with various doses of BPA (0, 4, or 40 mg/kg body weight (BW)/day) from gestation day (GD) 6 through postnatal day (PND) 20. There were no significant changes in body weight, liver weight, kidneys weight, testes weight, AGD, the ratio of AGD to BW, or the ratio of AGD to the cube root of BW in BPA exposed pups compared to the vehicle-exposed control. This suggests that prenatal and postnatal exposure (indirect exposure) to BPA (4-40 mg/kg/day, GD 6-PND 20) does not affect on somatic growth or AGD of F1 generation of male and female rats.
ISSN:0019-8366
1880-8026
DOI:10.2486/indhealth.40.375