AMELIORATIVE EFFECT OF CUCURBITA PEPO L. SEED EXTRACT AGAINST LEAD INDUCED EFFECTS ON THE SERUM AND TESTICULAR OXIDATIVE STATUS: AN IN VIVO VALIDATION

Lead (Pb) exposure is considered to be an alarming public health problem since evidence has mounted regarding its adverse impact on health and reproduction. The current research was intended to evaluate the ameliorative effects of Cucurbita pepo L. (pumpkin) against lead toxicity-induced oxidative s...

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Bibliographic Details
Published in:International journal of pharmaceutical sciences and drug research 2023-03, p.214-221
Main Authors: Nair, Amrutha B., PA, Raajeswari
Format: Article
Language:English
Online Access:Get full text
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Summary:Lead (Pb) exposure is considered to be an alarming public health problem since evidence has mounted regarding its adverse impact on health and reproduction. The current research was intended to evaluate the ameliorative effects of Cucurbita pepo L. (pumpkin) against lead toxicity-induced oxidative stress in experimental rats. Before the animal study, a preliminary phytochemical screening was done to detect the presence of various phytoconstituents in the seed extract. Thirty adult male wistar rats were selected and randomly divided into five groups for the experimental study. Group 1 served as the control while groups 2, 3, 4 and 5 were treated with 30 mg/kg lead acetate, 1000 mg/kg seed extract alone (high dose), 30 mg/kg lead acetate and 100 mg/kg seed extract (low dose) and 30 mg/kg lead acetate and 1000 mg/kg seed extract (high dose), respectively. Enzymatic antioxidant concentrations in serum and testis were found to check the response of antioxidants to lead toxicity. In lead treated group, increased oxidative stress was observed which was indicated by a significant (p
ISSN:0975-248X
0975-248X
DOI:10.25004/IJPSDR.2023.150214