Primary central nervous system Hodgkin’s lymphoma – A case report and review of literature

• Published in: Journal of neurosciences in rural practice 2025-01, p.1-7, Article 1
• Main Authors: Thrinadh, Botta, Karthikeyan, Kavindapadi Veerasamy, Raghavan, Vijayashree, Sathyaseelan, Masilamani, Ramesh, Vengalathur Ganesan
• Format: Article
• Language: English
• ISSN: 0976-3147; 0976-3155
• DOI: 10.25259/JNRP_402_2024

Hodgkin’s lymphoma (HL) is primarily a disease affecting the lymph nodes. Extranodal involvement is rare. Primary central nervous system involvement in HL is extremely rare. The diagnosis is established by morphology and distinct immune-histochemical staining of the biopsies. A 76-year-old male patient presented with speech disturbance and weakness of the right upper and lower limbs. Magnetic resonance imaging of the brain showed an intraparenchymal mass lesion in the left frontal lobe with features of a high-grade tumor. Craniotomy and complete excision of the mass lesion were done. With histopathological examination and immunohistochemistry, the diagnosis of HL was made. Whole-body positron emission tomography did not reveal any other focus. The patient is being followed up with further oncological management. Only 26 cases of primary HL have been reported in the literature. Hence, this case is presented for its rarity. The previously reported cases and the recent concepts in the pathogenesis and treatment have also been reviewed.