Possible Role of Intestinal Microbiome Representatives in Biotransformation of Aryl- and Pyridyl-Containing Phosphines and their Derivatives According to 31P NMR Spectroscopy Data

• Published in: The Bulletin of Irkutsk State University. Series Biology. Ecology 2023, Vol.45, p.32-45
• Main Authors: Pendyukhova, А. S., Dranitsa, I. S., Mikhailenko, V. L., Pristavka, А. А., Verkhoturova, S. I., Belogorlova, N. A., Arbuzova, S. N., Yurinova, G. V., Salovarova, V. P.
• Format: Article
• Language: English
• ISSN: 2073-3372
• DOI: 10.26516/2073-3372.2023.45.32

Organophosphorus compounds (OPCs) are used in many areas of human activity. Unique physicochemical properties and high biological activity not only determine the applied value of OPCs but also give them the properties of xenobiotics that are harmful to human health, which largely depend on the state of the endogenous microbiota. The purpose of this work is to assess the effect of pyridyl- and aryl-containing phosphines, their oxides, and sulfides on the growth of Bifidobacterium bifidum and Escherichia coli and to identify possible patterns of biotransformation of OPCs using 31P NMR spectroscopy. Bacteria were cultivated in thioglycollate medium containing the tested phosphorus compounds. At the stationary growth phase was determined the cell concentration and were recorded spectra 31P NMR. It was shown that the most reliable (p