Antigiardial Activity of Cupania dentata Bark and its Constituents

The MeOH extract of Cupania dentata bark (Sapindaceae) as well as its hexane, CH2Cl2, EtOAc, and BuOH fractions showed high activity against Giardia lamblia trophozoites (IC50 = 2.12-9.52 μg/mL). The phytochemical study of fractions resulted in the isolation of taraxerone (1), taraxerol (2), scopole...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Mexican Chemical Society 2017-10, Vol.56 (2)
Main Authors: Hernández-Chávez, Ignacio, Torres-Tapia, Luis W., Simá-Polanco, Paulino, Cedillo-Rivera, Roberto, Moo-Puc, Rosa, Peraza-Sánchez, Sergio R.
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The MeOH extract of Cupania dentata bark (Sapindaceae) as well as its hexane, CH2Cl2, EtOAc, and BuOH fractions showed high activity against Giardia lamblia trophozoites (IC50 = 2.12-9.52 μg/mL). The phytochemical study of fractions resulted in the isolation of taraxerone (1), taraxerol (2), scopoletin (3), and two mixtures of steroidal compounds. Taraxerone was the metabolite with the highest giardicidal activity (IC50 = 11.33 μg/mL).
ISSN:1870-249X
2594-0317
DOI:10.29356/jmcs.v56i2.305