Evaluation of the effectiveness of the appointment of acetylsalicylic acid for the prevention of obstetric complications by the method of logistic regression

• Published in: Reproductive health of woman (Online) 2021-06 (5), p.19-27
• Main Authors: Herasymchuk, V.О., Zahorodnia, O.S., Krukovets, D.Yu
• Format: Article
• Language: eng ; ukr
• ISSN: 2708-8723; 2708-8731
• DOI: 10.30841/2708-8731.5.2021.240021

Preeclampsia remains to be an urgent problem in the modern medicine, the main reason for which is the lack of high efficiency of treatment. One of the few methods with proven effectiveness is the prophylactic administration of aspirin at the beginning of the second trimester of pregnancy. At the same time, microcirculation disorders that underlie the development of preeclampsia are pathogenetically significant for other gestational complications.The objective: a study of the effectiveness of aspirin prescription for the prevention of preeclampsia and other complications during pregnancy using the logistic regression method.Materials and methods. The control group included 43 pregnant women with clinical criteria for preeclampsia. Forty six pregnant women with risk factors for preeclampsia who took acetylsalicylic acid from the 16-18 weeks of gestation formed the I group, and 46 pregnant women with risk factors for preeclampsia who did not take acetylsalicylic acid were included in the the II group. In all patients, on the basis of anamnesis data, risk factors and the course of the second trimester of pregnancy were analyzed, their correlation analysis and the use of acetylsalicylic acid were carried out, logistic regressions and simple decision trees were constructed.Results. The proposed logistic regression models have demonstrated their veracity by confirming the influence of traditional risk factors for the development of preeclampsia. At the same time, the use of these models allowed not only to prove the preventive effect of aspirin on the development of preeclampsia (the coefficient is statistically significant, with a negative sign), but also the ability to reduce the severity of preeclampsia. In addition, the negative sign of the coefficient was obtained when studying the effect of taking aspirin on such complications of pregnancy as premature birth and fetal growth retardation.Conclusions. 1. The use of a database of patients, statistical and model analysis of this dataset, allows you to establish and evaluate the relationship, their statistical significance between different factors. Based on the results of the research we can say with great confidence about the significant effect of prophylactic aspirin intake on reducing the risk of preeclampsia. 2. Taking aspirin reduces the likelihood of fetal growth retardation and premature birth. 3. The use of assisted reproductive technologies is positively correlated with the risk of developing preeclamp