Alginate–chitosan micro- and nanoparticles for transmucosal delivery of proteins

The properties of protein-containing micro- and nanoparticles that were produced from alginate and chitosan using the methods of layer-by-layer polyelectrolyte adsorption and ionotropic gelation have been compared. The encapsulation efficiency of proteins (aprotinin, interferon, and human insulin),...

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Bibliographic Details
Published in:Moscow University chemistry bulletin 2016-03, Vol.71 (2), p.127-133
Main Authors: Kirzhanova, E. A., Pechenkin, M. A., Demina, N. B., Balabushevich, N. G.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Summary:The properties of protein-containing micro- and nanoparticles that were produced from alginate and chitosan using the methods of layer-by-layer polyelectrolyte adsorption and ionotropic gelation have been compared. The encapsulation efficiency of proteins (aprotinin, interferon, and human insulin), the size and ζ-potential of the particles, the mucin binding, and the protein release under physiological conditions have been studied. The prospects for the possible mucosal application of the particles are discussed.
ISSN:0027-1314
1935-0260
DOI:10.3103/S002713141602005X