Flow Cytometry Analysis of G0/G1 Diploid Cell Fraction in Ovarian Cancer Tissue

The proportion of diploid cells in the G 0 / G 1 cell cycle phases was estimated by flow cytometry in 60 samples of stage III serous ovarian cancer tissue. The tumor tissue shows considerable heterogeneity with regard to the content of this tissue fraction, which ranged from 27 to 95% with a median...

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Bibliographic Details
Published in:Moscow University chemistry bulletin 2018-09, Vol.73 (5), p.244-247
Main Authors: Bogush, T. A., Mamichev, I. A., Borisenko, Iu. P., Bogush, E. A., Vichljantseva, N. O., Kirsanov, V. Ju
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Summary:The proportion of diploid cells in the G 0 / G 1 cell cycle phases was estimated by flow cytometry in 60 samples of stage III serous ovarian cancer tissue. The tumor tissue shows considerable heterogeneity with regard to the content of this tissue fraction, which ranged from 27 to 95% with a median of 73%. Statistically significant differences in the size of this fraction were identified by comparing tumor subgroups sensitive and resistant to first-line platinum-taxane chemotherapy. Predictive significance of the G 0 / G 1 fraction was concluded and quantitative evaluation of this fraction is recommended for clinical use.
ISSN:0027-1314
1935-0260
DOI:10.3103/S0027131418050024