Molecular Basis of Intellect: Proton Mechanism of Recording Information

The concept of the molecular foundations of neurological memory is formulated based on the physicochemical principles of the functioning of biomolecules. The concept proceeds from the position that a neuroimage is formed in the form of a matrix of conducting acetylcholine synaptic contacts, while th...

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Bibliographic Details
Published in:Moscow University chemistry bulletin 2022-02, Vol.77 (1), p.38-41
Main Author: Varfolomeev, S. D.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Summary:The concept of the molecular foundations of neurological memory is formulated based on the physicochemical principles of the functioning of biomolecules. The concept proceeds from the position that a neuroimage is formed in the form of a matrix of conducting acetylcholine synaptic contacts, while the key is the reversible inactivation of acetylcholinesterase by hydrogen ions, the products of acetylcholine hydrolysis. Fundamentally important and new is the idea that storing information in the form of a neuroimage is related to the pH-blockade of acetylcholinesterase activity in the synaptic cleft, which makes it possible for each synapse that forms a neuroimage to continuously participate in signal transmission. The mechanisms of the functioning of the elementary neural network, which provide the recording–reading of information, are considered, and the performance of the system is assessed.
ISSN:0027-1314
1935-0260
DOI:10.3103/S0027131422010072