Immunochemical activity of the Yersinia pseudotuberculosis B-antigen

A hybridoma panel producing monoclonal antibodies to immunochemically nonidentical anti-genic epitopes of a protein nature located in the outer membrane of Yersinia pseudotuberculosis was obtained. It was revealed that the previously identified B-antigen that protects laboratory animals from experim...

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Bibliographic Details
Published in:Molecular genetics, microbiology and virology microbiology and virology, 2015-04, Vol.30 (2), p.93-100
Main Authors: Byvalov, A. A., Dudina, L. G., Chernyad’ev, A. V., Konyshev, I. V., Litvinets, S. G., Ovodov, Yu. S.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Experimental Works
Life Sciences
Microbiology
Molecular Medicine
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Summary:A hybridoma panel producing monoclonal antibodies to immunochemically nonidentical anti-genic epitopes of a protein nature located in the outer membrane of Yersinia pseudotuberculosis was obtained. It was revealed that the previously identified B-antigen that protects laboratory animals from experimental plague being used for active immunization was detected using monoclonal antibodies both against the men-tioned protein determinants and determinants of lipopolysaccharide O-side chains. B-antigen is a compo-nent of the Y. pseudotuberculosis outer membrane, which is egested in the form of vesicles (OMVs) by bacteria cultivated in a fluid nutrient medium.
ISSN:0891-4168
1934-841X
DOI:10.3103/S0891416815020032