Search for Prognostic Factors in Head and Neck Cancer

Kraxner H, Tamás L, Járay B, Ribári O, Szentirmay Z, Szende B. Search for prognostic factors in head and neck cancer. Acta Otolaryngol (Stockh) 1997; 527: 145-149. Fifteen patients with head and neck carcinoma were treated with irradiation (14-70 Gy telecobalt). Apoptotic and mitotic index, DNA inde...

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Published in:Acta oto-laryngologica 1997, Vol.117 (S527), p.145-149
Main Authors: Kraxner, Helga, Tamás, László, Járay, Balázs, Ribári, Ottó, Szentirmay, Zoltán, Szende, Béla
Format: Article
Language:English
Subjects:
apoptosis
head and neck cancer
prognosis
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Summary:Kraxner H, Tamás L, Járay B, Ribári O, Szentirmay Z, Szende B. Search for prognostic factors in head and neck cancer. Acta Otolaryngol (Stockh) 1997; 527: 145-149. Fifteen patients with head and neck carcinoma were treated with irradiation (14-70 Gy telecobalt). Apoptotic and mitotic index, DNA index, ratio of cells in S phase, p53 protein overexpression in untreated tumours as well as the changes of these parameters after the first 2 Gy irradiation-except proliferative kinetics parameters-were examined in order to determine the prognostic value of these factors. The data show that inducibility of apoptosis is very low in head and neck carcinomas which correlate with the unfavourable prognosis. The decrease in mitotic index after the first 2 Gy irradiation, which occurred in 7 cases-5 of them still alive-indicates a better chance for relatively longer survival. In immunohis-tochemically p53 positive tumours frequently occurring aneuploidy and elevated S-phase rate were found.
ISSN:0001-6489
1651-2251
DOI:10.3109/00016489709124059