Gaba Uptake by Rabbit Restiform Body Homogenates

Restiform body (inferior cerebellar peduncle) preparations were obtained from rabbit brain stem slices and homogenized. When challenged with labelled GABA, these homogenates took it up briskly. We have characterized pharmacologically this uptake which resulted almost equally neuronal and glial. The...

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Bibliographic Details
Published in:International journal of neuroscience 2001-01, Vol.107 (1-2), p.103-112
Main Authors: Hydèn, H., Cupello, A., Rapallino, M. V., Scarrone, S., Seitun, A.
Format: Article
Language:English
Subjects:
Acetanilides - pharmacokinetics
Animals
Biological and medical sciences
Brain Stem - metabolism
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Cerebellum - metabolism
Fundamental and applied biological sciences. Psychology
GABA uptake
gamma-Aminobutyric Acid - pharmacokinetics
Glial uptake
Inferior cerebellar peduncle
Neuroglia - metabolism
Neuronal uptake
Rabbits
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
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Summary:Restiform body (inferior cerebellar peduncle) preparations were obtained from rabbit brain stem slices and homogenized. When challenged with labelled GABA, these homogenates took it up briskly. We have characterized pharmacologically this uptake which resulted almost equally neuronal and glial. The neuronal component of the GABA uptake might be due to the adjacent cochlear nuclei coming along in the preparations, whereas the glial component probably belongs to the restiform body proper. Another possibility is that actually both components are due to the myelinated fibers and glia which make up the restiform body.
ISSN:0020-7454
1563-5279
1543-5245
DOI:10.3109/00207450109149760