Decrease by 50% of plasma IgA tissue transglutaminase antibody concentrations within 2 months after start of gluten-free diet in children with celiac disease used as a confirming diagnostic test

Background Histological examination of small bowel biopsies is normally the gold standard for the diagnosis of celiac disease (CD). The objective of this study was to investigate whether the rate of decreases in elevated plasma IgA tissue transglutaminase antibody (IgA-tTG) and/or IgG deamidated gli...

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Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation 2016-02, Vol.76 (2), p.128-132
Main Authors: Lund, Flemming, Hermansen, Mette N., Pedersen, Merete F., Hillig, Thore, Lavant, Ewa, Valtonen-André, Camilla, Sölétormos, György
Format: Article
Language:English
Subjects:
Adolescent
Autoantibodies - blood
Celiac Disease - blood
Celiac Disease - diagnosis
Celiac Disease - diet therapy
Child
Child, Preschool
Clinical Medicine
diagnostic test
Female
Gastroenterologi
Gastroenterology and Hepatology
Glutaminase - immunology
Half-Life
half-life of antibodies
HLA typing
Humans
Immunoglobulin A
Immunoglobulin A - blood
immunoglobulin G
Infant
Klinisk medicin
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Treatment Outcome
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Summary:Background Histological examination of small bowel biopsies is normally the gold standard for the diagnosis of celiac disease (CD). The objective of this study was to investigate whether the rate of decreases in elevated plasma IgA tissue transglutaminase antibody (IgA-tTG) and/or IgG deamidated gliadin peptides antibody (IgG − DGP) concentrations could be used as a confirming test for CD in children on a gluten-free diet (GFD) when biopsy was omitted in the diagnostic process. Methods In this retrospective study we compared children (≤18 years old) with a CD-confirming biopsy (n = 16) to children without a biopsy (n = 18). After initiation of GFD the antibody half-life (the time (T ½ ) when the antibody concentration is 50% decreased) was determined in all children. Results Children with a biopsy (IgA-tTG, T ½  = 1.9 months; IgG − DGP, T ½  = 2.2 months) and children without a biopsy (IgA-tTG, T ½  = 1.6 months; IgG − DGP, T ½  = 2.7 months) had comparable T ½ (mean) results (p 
ISSN:0036-5513
1502-7686
1502-7686
DOI:10.3109/00365513.2015.1124449