Determinants of visfatin in type 2 diabetes patients with diabetic kidney disease: Relationship to inflammation, adiposity and undercarboxylated osteocalcin

Background Visfatin is a proinflammatory molecule with possible actions on glucose metabolism. Interactions to bone metabolism and undercarboxylated osteocalcin (uOC) in diabetic patients (T2DP) with diabetic kidney disease (DKD) have not been reported. Materials and methods We included 51 incident...

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Published in:Scandinavian journal of clinical and laboratory investigation 2016-04, Vol.76 (3), p.217-225
Main Authors: Kacso, Alex C., Bondor, Cosmina I., Coman, Anca L., Potra, Alina R., Georgescu, Carmen E.
Format: Article
Language:English
Subjects:
Adipokines
Adiposity
Aged
albuminuria
Case-Control Studies
Cytokines - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - pathology
Diabetes Mellitus, Type 2 - physiopathology
Diabetic Nephropathies - blood
Diabetic Nephropathies - pathology
Diabetic Nephropathies - physiopathology
Female
Glomerular Filtration Rate
glucose metabolism disorders
Humans
inflammation
kidney disease
Male
Middle Aged
Nicotinamide Phosphoribosyltransferase - blood
Osteocalcin - blood
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Summary:Background Visfatin is a proinflammatory molecule with possible actions on glucose metabolism. Interactions to bone metabolism and undercarboxylated osteocalcin (uOC) in diabetic patients (T2DP) with diabetic kidney disease (DKD) have not been reported. Materials and methods We included 51 incident T2DP with DKD. History, laboratory evaluation, anthropometry, visfatin, uOC were obtained. Fifteen T2DP without DKD were used as controls. Results Visfatin was similar in DKD patients and controls: 1.56(0.97-3.03) versus 2.04(1.08-3.21) ng/mL, p = 0.51. In controls, visfatin positively correlated with diabetes duration (r = 0.63, p = 0.01) and negatively with uOC (r = −0.57, p = 0.03). In multivariate regression, diabetes duration remained significant (p = 0.01). In patients with DKD, visfatin was positively linked to C reactive protein (r = 0.27, p = 0.05), tricipital skin fold (TSF) (r = 0.41, p = 0.004) and leukocytes (r = 0.37, p = 0.01); the latter two parameters predicted visfatin in multivariate model (p = 0.001). In normoalbuminuric patients, visfatin was linked to body mass index (r = 0.32, p = 0.04), waist circumference (r = 0.42, p 
ISSN:0036-5513
1502-7686
DOI:10.3109/00365513.2015.1137349