Should we interpret the results of 'two-step' glucose screening again according to the obstetric outcomes?

• Published in: Journal of obstetrics and gynaecology 2016-08, Vol.36 (6), p.705-709
• Main Authors: Seval, Mehmet Murat, Cavkaytar, Sabri, Atak, Zeliha, Cagman, Mustafa
• Format: Article
• Language: English
• Subjects: Adult; Birth Weight; Blood Glucose - analysis; Clinical outcomes; Diabetes; Diabetes, Gestational - diagnosis; diabetic complications; Female; Fetal Macrosomia - etiology; Gestastional diabetes mellitus; Gestational Age; glucose screening; Glucose Tolerance Test - statistics & numerical data; Humans; Infant, Newborn; macrosomia; Male; Pregnancy; Pregnancy Complications - etiology; Pregnancy Outcome; Prenatal Care - statistics & numerical data; Retrospective Studies
• ISSN: 0144-3615; 1364-6893
• DOI: 10.3109/01443615.2015.1134459

We aimed to re-evaluate the 'two-step' antenatal glucose screening programme in relation to maternal and foetal outcomes in pregnant women screened for gestational diabetes mellitus and to compare maternal and foetal outcomes between different groups divided according to glucose tolerance test results. Two-thousand four-hundred and two pregnant women attending for antenatal care were recruited retrospectively for the study. Mean birthweight for pregnancies with single-value abnormality (SVA) in 100-g oral glucose tolerance test (OGTT) was significantly higher than the control group [3420 ± 378 vs. 3294 ± 444]. We found a significantly higher rate of macrosomia in the subgroup of 50-g glucose challenge test (GCT) between 130 and 140 mg/dl [9.7% vs. 4.8%]. Pregnant women whose 50-g GCT results are between 130 and 140 mg/dl or who have SVA in 100-g OGTT not only have gestational diabetes, but are also at increased risk for diabetic complications.