Formulation of wax oxybenzone microparticles using a factorial approach

Oxybenzone wax microparticles (MPs) were prepared by the hydrophobic congealable disperse phase method. The formulation of oxybenzone-loaded MPs was optimized using a 24 experimental design. Factorial analysis indicated that the main MP characteristics were influenced by initial drug loading, emulsi...

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Bibliographic Details
Published in:Journal of microencapsulation 2010-11, Vol.27 (7), p.628-639
Main Authors: Gomaa, Y. A., Darwish, I. A., Boraei, N. A., El-Khordagui, L. K.
Format: Article
Language:English
Subjects:
Benzophenones - chemistry
Benzophenones - pharmacology
Biological and medical sciences
carnauba wax
Chemistry, Pharmaceutical - methods
Diseases of the skin. Cosmetics
Emulsions - chemistry
Emulsions - pharmacology
factorial design
General pharmacology
Medical sciences
Microscopy, Electron, Scanning
Microspheres
Oxybenzone
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Solubility
Spectrophotometry, Infrared
sunscreen
Sunscreening Agents - chemistry
Sunscreening Agents - pharmacology
Waxes - chemistry
Waxes - pharmacology
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Summary:Oxybenzone wax microparticles (MPs) were prepared by the hydrophobic congealable disperse phase method. The formulation of oxybenzone-loaded MPs was optimized using a 24 experimental design. Factorial analysis indicated that the main MP characteristics were influenced by initial drug loading, emulsification speed, emulsifier concentration and hydrophilic-lipophilic balance. MPs were spherical with 50.5-88.1 µm size range, 17.8-38.9 drug content in mg/100 mg MPs and 33.1-87.2% oxybenzone release in 1 h. A wide range of sunscreen delivery systems suitable for different formulation purposes were generated which may contribute to the advanced formulation of sunscreen products with improved performance.
ISSN:0265-2048
1464-5246
DOI:10.3109/02652048.2010.506580