Semi-IPN chitosan/polyvinylpyrrolidone microspheres and films: sustained release and property optimisation

Abstract A set of chitosan-polyvinylpyrrolidone (CH-PVP) microspheres were prepared as semi-inter penetrating networks (semi-IPN) and loaded with 5-fluorouracil. In vitro release studies showed faster release for semi-IPN microspheres compared to pure CH samples, and the total release was achieved i...

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Bibliographic Details
Published in:Journal of microencapsulation 2013-01, Vol.30 (8), p.762-770
Main Authors: Ozerkan, Taylan, Aydemir Sezer, Umran, Deliloglu Gurhan, smet, Gulce z, Sultan, Hasirci, Nesrin
Format: Article
Language:English
Subjects:
5-fluorouracil
Adenocarcinoma - drug therapy
Antimetabolites, Antineoplastic - administration & dosage
Antimetabolites, Antineoplastic - pharmacology
Biological and medical sciences
Breast Neoplasms - drug therapy
Cell Line
chitosan
Chitosan - chemistry
controlled release
Delayed-Action Preparations - chemistry
Female
Fluorouracil - administration & dosage
Fluorouracil - pharmacology
General pharmacology
Humans
Medical sciences
Microspheres
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
polyvinylpyrrolidone
Povidone - chemistry
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Summary:Abstract A set of chitosan-polyvinylpyrrolidone (CH-PVP) microspheres were prepared as semi-inter penetrating networks (semi-IPN) and loaded with 5-fluorouracil. In vitro release studies showed faster release for semi-IPN microspheres compared to pure CH samples, and the total release was achieved in about 20-30 days, depending on the composition. In vitro cell studies were achieved against human breast adenocarcinoma cell line cells where adsorption of cells on microspheres with a significant decrease in their number was obtained. Meanwhile, the CH-PVP films, which were prepared with the same compositions as in the microspheres, demonstrated an increase in strength from 66 to 118 MPa as the PVP content was decreased. It can be concluded that the prepared CH-PVP semi-IPN microspheres are novel promising carriers compared to pure CH microspheres since it becomes possible to adjust stability and hydrophilicity of the microspheres as well as the release rates of the drugs from the microspheres by changing the ratio of CH/PVP composition.
ISSN:0265-2048
1464-5246
DOI:10.3109/02652048.2013.788084