Retinal Vasculature Fractal Dimension Measures Vessel Density

Purpose: The goal of this study was to provide the empirical evidence of fractal dimension as an indirect measure of retinal vasculature density. Materials and methods: Two hundred retinal samples of right eye [57.0% females (n = 114) and 43.0% males (n = 86)] were selected from baseline visit. A cu...

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Bibliographic Details
Published in:Current eye research 2016-06, Vol.41 (6), p.823-831
Main Authors: Ab Hamid, Fadilah, Che Azemin, Mohd Zulfaezal, Salam, Adzura, Aminuddin, Amilia, Mohd Daud, Norsyazwani, Zahari, Ilyanoon
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Child
Female
fractal dimension
Humans
Image Processing, Computer-Assisted - methods
Male
Middle Aged
Reference Values
Reproducibility of Results
retinal
Retinal Vessels - anatomy & histology
Retrospective Studies
vascular
vessel density
Young Adult
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Summary:Purpose: The goal of this study was to provide the empirical evidence of fractal dimension as an indirect measure of retinal vasculature density. Materials and methods: Two hundred retinal samples of right eye [57.0% females (n = 114) and 43.0% males (n = 86)] were selected from baseline visit. A custom-written software was used for vessel segmentation. Vessel segmentation is the process of transforming two-dimensional color images into binary images (i.e. black and white pixels). The circular area of approximately 2.6 optic disc radii surrounding the center of optic disc was cropped. The non-vessels fragments were removed. FracLac was used to measure the fractal dimension and vessel density of retinal vessels. Results: This study suggested that 14.1% of the region of interest (i.e. approximately 2.6 optic disk radii) comprised retinal vessel structure. Using correlation analysis, vessel density measurement and fractal dimension estimation are linearly and strongly correlated (R = 0.942, R 2  = 0.89, p 
ISSN:0271-3683
1460-2202
DOI:10.3109/02713683.2015.1056375