Mast Cells Influence the Proliferation Rate of Myeloma Plasma Cells

In multiple myeloma (MM), mast cells (MCs) modify bone marrow microenvironment. In order to estimate whether MC density (MCD) in active MM bone marrows relates to the proliferative activity of plasma cells, we estimated in 42 patients MCD, microvascular density (MVD), and the Ki-67 proliferation ind...

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Bibliographic Details
Published in:Cancer investigation 2015-04, Vol.33 (4), p.137-141
Main Authors: Pappa, Constantina A., Tsirakis, George, Stavroulaki, Emilia, Kokonozaki, Maria, Xekalou, Athina, Konsolas, Ioannis, Alexandrakis, Michael G.
Format: Article
Language:English
Subjects:
Adult
Aged
Angiogenesis
Biochemical markers
CD40 Ligand - analysis
Cell Proliferation
Female
Humans
L-Lactate Dehydrogenase - blood
Male
Mast Cells - physiology
Middle Aged
Multiple Myeloma - pathology
Myeloma
Neovascularization, Physiologic
Plasma Cells - physiology
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Summary:In multiple myeloma (MM), mast cells (MCs) modify bone marrow microenvironment. In order to estimate whether MC density (MCD) in active MM bone marrows relates to the proliferative activity of plasma cells, we estimated in 42 patients MCD, microvascular density (MVD), and the Ki-67 proliferation index (PI) (immunohistochemical expression of tryptase, CD31, and Ki-67). MCD correlated with Ki-67 PI (p < .001), suggesting the important participation of MCs in MM biology and growth; MCs enhance angiogenesis and produce cytokines with growth effects on myeloma cells. Therefore, MCs could be valuable targets for therapeutic interventions.
ISSN:0735-7907
1532-4192
DOI:10.3109/07357907.2015.1008639