microRNA-21 Expression is Elevated in Esophageal Adenocarcinoma After Neoadjuvant Chemotherapy

ABSTRACTWe investigated whether microRNA-21 and microRNA-148a are predictive for neoadjuvant treatment in esophageal adenocarcinoma. Thirty-six patients with neoadjuvant therapy and surgical resection were included. FFPE tissue from biopsy and esophagectomy were analyzed using RT-qPCR. Results were...

Full description

Saved in:
Bibliographic Details
Published in:Cancer investigation 2015-07, Vol.33 (6), p.246-250
Main Authors: Ilhan-Mutlu, Aysegül, Tezcan, Gülcin, Schoppmann, Sebastian F., Preusser, Matthias, Spyridoula, Kommata, Karanikas, Georgios, Birner, Peter
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - drug therapy
Adenocarcinoma - genetics
Adenocarcinoma - metabolism
Aged
Chemotherapy, Adjuvant
Disease-Free Survival
Esophageal cancer
Esophageal Neoplasms - drug therapy
Esophageal Neoplasms - genetics
Esophageal Neoplasms - metabolism
FDG-PET-CT
Female
Humans
Male
microRNA-148a
microRNA-21
MicroRNAs - biosynthesis
Middle Aged
Multimodal Imaging
Neoadjuvant Therapy
Positron-Emission Tomography
Proportional Hazards Models
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Tomography, X-Ray Computed
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACTWe investigated whether microRNA-21 and microRNA-148a are predictive for neoadjuvant treatment in esophageal adenocarcinoma. Thirty-six patients with neoadjuvant therapy and surgical resection were included. FFPE tissue from biopsy and esophagectomy were analyzed using RT-qPCR. Results were correlated to histological tumor regression, histopathological variables, FDG-PET-CT and survival. MicroRNA-21 was significantly higher in esophagectomies than in corresponding biopsies (p = .027). No association of microRNA-21 or microRNA-148a expression in tissue specimens with other clinical parameters was present. Although no influence of microRNA-21 and microRNA-148a on the response to neoadjuvant therapy was seen, upregulation of microRNA-21 might represent an escape mechanism of tumor cells.
ISSN:0735-7907
1532-4192
DOI:10.3109/07357907.2015.1024319