24-HOUR TEMPORAL PATTERN OF NTPDase AND 5′-NUCLEOTIDASE ENZYMES IN RAT BLOOD SERUM

Circadian rhythms represent an important mechanism to prepare the organism for environmental variations. ATP, ADP, AMP, and adenosine can act as extracellular messengers in a range of biological processes and are metabolized by a number of enzymes, including NTPDases and 5′-nucleotidase. In the pres...

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Bibliographic Details
Published in:Chronobiology international 2010-12, Vol.27 (9-10), p.1751-1761
Main Authors: Detanico, Bernardo Carraro, de Souza, Andressa, Medeiros, Liciane Fernandes, Rozisky, Joanna Ripoll, Caumo, Wolnei, Hidalgo, Maria Paz Loayza, Battastini, Ana Maria Oliveira, Torres, Iraci Lucena da Silva
Format: Article
Language:English
Subjects:
5'-Nucleotidase - blood
5′-Nucleotidase
Adenine nucleotides
Adenosine Diphosphate - metabolism
Adenosine Triphosphatases - blood
Adenosine Triphosphate - metabolism
Animals
Apyrase - blood
Circadian Rhythm
Corticosterone - blood
Kinetics
Male
Melatonin - blood
NTPDase
Nucleotidases - blood
Nucleotide hydrolysis
Rats
Rats, Wistar
Temporal pattern
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Summary:Circadian rhythms represent an important mechanism to prepare the organism for environmental variations. ATP, ADP, AMP, and adenosine can act as extracellular messengers in a range of biological processes and are metabolized by a number of enzymes, including NTPDases and 5′-nucleotidase. In the present study the authors report that ATPase and ADPase activities present 24-h temporal variations that peak during dark (activity) span. These findings suggest that this enzymatic temporal pattern in blood serum might be important for the normal physiology and function of the organism through the maintenance of extracellular nucleotides at physiological levels. (Author correspondence: iracitorres@gmail.com)
ISSN:0742-0528
1525-6073
DOI:10.3109/07420528.2010.512992