Prevalence of neuroleptic-induced movement disorders: an 8-year follow-up study in chronic schizophrenia inpatients

Background: Atypical antipsychotic drug use by schizophrenia patients in Estonia increased from 32% in 2004 to 61% in 2009. Aims: To assess the prevalence of neuroleptic-induced movement disorders in the Estonian institutionalized population of schizophrenia patients twice over a period of eight yea...

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Bibliographic Details
Published in:Nordic journal of psychiatry 2016-10, Vol.70 (7), p.498-502
Main Authors: Parksepp, Madis, Ljubajev, Ülle, Täht, Karin, Janno, Sven
Format: Article
Language:English
Subjects:
Adult
Aged
Akathisia
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - adverse effects
Antipsychotic treatment
Dyskinesia, Drug-Induced - epidemiology
Estonia - epidemiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neuroleptic-induced parkinsonism
Prevalence
Schizophrenia
Schizophrenia - drug therapy
Schizophrenia - epidemiology
Tardive dyskinesia
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Summary:Background: Atypical antipsychotic drug use by schizophrenia patients in Estonia increased from 32% in 2004 to 61% in 2009. Aims: To assess the prevalence of neuroleptic-induced movement disorders in the Estonian institutionalized population of schizophrenia patients twice over a period of eight years, before and after introduction of atypical antipsychotic drugs using DSM-IV criteria. Methods: DSM-IV criteria and specific rating scales were used to evaluate the prevalence of neuroleptic-induced movement disorders among 72 patients who participated in the study in 2009 compared to 99 patients who participated in 2001. Results: Despite increased use of atypical antipsychotics in the study population (up to 30% from 20%), the proportion of movement disorder-free population remained the same over 8 years - 38.9% in 2001 versus 38.4% in 2009. There were significant intra-individual fluctuations. Use of a typical antipsychotic resulted in an almost seven times higher risk of tardive dyskinesia after 8 years. Doses of antipsychotic drugs had no effect on the severity of neuroleptic-induced movement disorders. Conclusions: Unfortunately, in 18% of patients the switch of medication from typical to atypical did not change the overall prevalence of neuroleptic-induced movement disorders in the group. The long-term benefit of atypical antipsychotics requires further research in patients who are treated with antipsychotics for years.
ISSN:0803-9488
1502-4725
DOI:10.3109/08039488.2016.1164245