Expression of Vascular Endothelial Growth Factor (VEGF) in Macrophages, Fibroblasts, and Endothelial Cells in Pterygium Treated with 5-Fluorouracil

Abstract Purpose: To evaluate the VEGF expression in macrophages, fibroblasts, and endothelial cells from pterygium before and after 5-fluorouracil (5-FU) exposure. Methods: 68 excised pterygia (42 primary and 26 recurrent) were studied by immunohistochemistry, to analyze its expression in cells fro...

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Bibliographic Details
Published in:Seminars in ophthalmology 2015-05, Vol.30 (3), p.171-176
Main Authors: Hoyama, Erika, Viveiros, Magda Massae Hata, Shiratori, Claudia, Oliveira, Deilson Elgui de, Padovani, Carlos Roberto, Selva, Dinesh, Schellini, Silvana Artioli
Format: Article
Language:English
Subjects:
Adult
Aged
Angiogenesis
Antimetabolites - therapeutic use
antimitotic
Endothelial Cells - metabolism
eye
Female
Fibroblasts - metabolism
Fluorouracil - therapeutic use
Humans
Immunohistochemistry
Macrophages - metabolism
Male
Middle Aged
neovascularization
Pterygium - drug therapy
Pterygium - metabolism
Vascular Endothelial Growth Factor A - metabolism
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Summary:Abstract Purpose: To evaluate the VEGF expression in macrophages, fibroblasts, and endothelial cells from pterygium before and after 5-fluorouracil (5-FU) exposure. Methods: 68 excised pterygia (42 primary and 26 recurrent) were studied by immunohistochemistry, to analyze its expression in cells from pterygium and normal conjunctiva. VEGF expression was evaluated before and after a 5-FU subconjunctival injection 15 days prior to surgery. Results: Expression in macrophages was moderate in normal conjunctiva and low to moderate in pterygium tissues. In fibroblasts, it was negative or low in both tissues. Pterygium had a higher proportion of high VEGF expression in endothelial cells compared to normal tissue (p 
ISSN:0882-0538
1744-5205
DOI:10.3109/08820538.2013.835838