Breakage of B Cell Tolerance and Autoantibody Production in Anti-erythrocyte Transgenic Mice

In summary, there are two pathways for activation of peritoneal B-1 cells in HL mice: T cell-dependent and T cell-independent pathways. In both pathways, IL-10 is suggested to play an important role (Fig. 1). We have not yet known what type of cells secrete IL-10 by and whether other soluble factors...

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Bibliographic Details
Published in:International reviews of immunology 1999, Vol.18 (3), p.259-270
Main Authors: Nisitani, Sazuku, Honjo, Tasuku
Format: Article
Language:English
Subjects:
Animals
Autoantibodies - biosynthesis
Autoantibody
B cell tolerance
B-Lymphocytes - immunology
Erythrocytes - immunology
Helper T cell
Humans
Immune Tolerance
Mice
Mice, Transgenic
Transgenic mice
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Summary:In summary, there are two pathways for activation of peritoneal B-1 cells in HL mice: T cell-dependent and T cell-independent pathways. In both pathways, IL-10 is suggested to play an important role (Fig. 1). We have not yet known what type of cells secrete IL-10 by and whether other soluble factors are involved in each pathway. These questions are to be elucidated by further studies on HL mice.
ISSN:0883-0185
1563-5244
DOI:10.3109/08830189909043029