In-Vitro Platelet Hyperaggregation and Hypersecretion Associated with the Use of Fish Oil in Healthy Children

• Published in: Pediatric hematology and oncology 2013-11, Vol.30 (8), p.688-697
• Main Authors: Alioglu, Bulent, Zengin, Tugba, Dindar, Nermin, Tapci, Ayse Esra, Dallar, Yildiz
• Format: Article
• Language: English
• Subjects: Blood Platelets - cytology; Blood Platelets - metabolism; Child; Child, Preschool; children; Collagen - pharmacology; Dietary Supplements; Female; fish oil; Fish Oils - administration & dosage; Follow-Up Studies; Humans; Male; Platelet Aggregation - drug effects; platelet aggregation tests; platelet function tests; Platelet Function Tests - methods; platelet secretion tests
• ISSN: 0888-0018; 1521-0669
• DOI: 10.3109/08880018.2012.753561

Objective: The aim of this study is to evaluate how fish oil supplementation in children affects platelet function tests in vitro. Materials and Methods: The study included 62 children (20 healthy children without any medications and 42 healthy children who volunteered to take fish oil supplementation) aged between 2 and 12 years. In the group of children taking fish oil supplementation, the baseline, fourth week, and eighth week values for platelet function tests were obtained. Results: In the platelet aggregation tests induced by high dose of ADP after 8 weeks, the values were significantly higher compared with the values measured before the use of fish oil. The fish oil-supplemented group's values showed an increase in the fourth-week measurements compared with the control group and the baseline measurements in terms of platelet secretion test induced by collagen, standard dose of thrombin, and high-dose thrombin. Platelet secretion tests induced by standard dose of ADP at the end of the eighth week showed an increase compared with baseline test values. Conclusion: This study was done in in-vitro conditions wherein the platelet function in the pediatric age group was analyzed and it was found that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) present in fish oil especially exhibit in-vitro hyperaggregation and increase the secretion of platelets. As a result of this, we consider that it is necessary to be careful while using fish oil supplementation in children as an antithrombotic agent and for a variety of other indications.