Peripheral blood lymphocytes analysis detects CD100/SEMA4D alteration in systemic sclerosis patients

It was suggested that the immune system plays an important role at least in the amplification of the main elements in systemic sclerosis (SSc), an autoimmune disease with an incompletely elucidated pathogenesis. Elucidation of the mechanisms involved in the interaction between T and B cells, major p...

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Bibliographic Details
Published in:Autoimmunity (Chur, Switzerland) Switzerland), 2011-08, Vol.44 (5), p.427-436
Main Authors: Besliu, Alina, Banica, Leontina, Predeteanu, Denisa, Vlad, Violeta, Ionescu, Ruxandra, Pistol, Gina, Opris, Daniela, Berghea, Florian, Stefanescu, Maria, Matache, Cristiana
Format: Article
Language:English
Subjects:
Adult
Antigens, CD - blood
Antigens, CD - genetics
Antigens, CD - immunology
Antigens, CD - metabolism
B cells
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
CD100
CD4-CD8 Ratio
CD72
Female
Gene Expression Regulation - immunology
Humans
Immunophenotyping
Lymphocytes - immunology
Lymphocytes - metabolism
Middle Aged
Scleroderma, Systemic - blood
Scleroderma, Systemic - genetics
Scleroderma, Systemic - immunology
Scleroderma, Systemic - physiopathology
Semaphorins - blood
Semaphorins - genetics
Semaphorins - immunology
Semaphorins - metabolism
Systemic sclerosis
T cells
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Summary:It was suggested that the immune system plays an important role at least in the amplification of the main elements in systemic sclerosis (SSc), an autoimmune disease with an incompletely elucidated pathogenesis. Elucidation of the mechanisms involved in the interaction between T and B cells, major players of the immune system, could contribute to a better understanding of some of clinical and pathological manifestations of SSc. Recently, abnormalities in Semaphorin 4D (Sema4D/CD100) or CD72, two contrareceptors involved in T and B cells cooperation, were associated with autoimmunity. Therefore, we investigated CD100 and CD72 expression level on T and B cells in attempting to establish their role in SSc pathogenesis. The results revealed augmented percentages of CD100high T and B cells, significantly increased expression of CD100 on CD4+ T cells and frequently detectable levels of soluble CD100 in SSc patient sera compared to healthy donors. In SSc, CD100 dysregulations were associated with anti-Scl70 antibodies production, disease type, thickening of skin, disease duration, or with active inflammation processes. In consequence, dysregulations in CD100 expression and release could play a role in SSc development and/or maintenance.
ISSN:0891-6934
1607-842X
DOI:10.3109/08916934.2010.541171