Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis

A dual role of B cells in experimental autoimmune encephalomyelitis (EAE), the animal model of the human autoimmune disease multiple sclerosis (MS), has been established. In the first role, B cells contribute to the pathogenesis of EAE through the production of anti-myelin antibodies that contribute...

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Bibliographic Details
Published in:Autoimmunity (Chur, Switzerland) Switzerland), 2012-08, Vol.45 (5), p.388-399
Main Authors: Mann, Monica K., Ray, Avijit, Basu, Sreemanti, Karp, Christopher L., Dittel, Bonnie N.
Format: Article
Language:English
Subjects:
Animals
Antibodies - immunology
B cell
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
B-Lymphocytes, Regulatory - immunology
B-Lymphocytes, Regulatory - metabolism
Cytokines - biosynthesis
Cytokines - immunology
Encephalomyelitis, Autoimmune, Experimental - etiology
Encephalomyelitis, Autoimmune, Experimental - immunology
experimental autoimmune encephalomyelitis
Humans
immune regulation
immunoglobulin
Immunoglobulins - immunology
multiple sclerosis
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Summary:A dual role of B cells in experimental autoimmune encephalomyelitis (EAE), the animal model of the human autoimmune disease multiple sclerosis (MS), has been established. In the first role, B cells contribute to the pathogenesis of EAE through the production of anti-myelin antibodies that contribute to demyelination. On the contrary, B cells have also been shown to have protective functions in that they play an essential role in the spontaneous recovery from EAE. In this review, we summarize studies conducted in a number of species demonstrating the conditions under which B cells are pathogenic in EAE. We also discuss the phenotype and anti-inflammatory mechanisms of regulatory B cells.
ISSN:0891-6934
1607-842X
DOI:10.3109/08916934.2012.665523