Sicam-1, sCD95 and sCD95L Levels in Chronic Liver Diseases of Different Etiology

Abstract The release of soluble circulating molecules represents a prominent feature during the course of immune-mediated clinical conditions. To further assess the relationship between serum concentrations of adhesion or apoptotic-related soluble structures and liver diseases, we evaluated the leve...

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Bibliographic Details
Published in:Immunopharmacology and immunotoxicology 2000-01, Vol.22 (1), p.19-33
Main Authors: Tortorella, Cosimo, Sacco, Rodolfo, Orlando, Piero, Salerno, Maria Teresa, Schiraldi, Oronzo, Antonaci, Salvatore
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Hepatocellular - metabolism
CD95 antigen
CD95L protein
fas Receptor - blood
fas Receptor - metabolism
Female
Hepatitis C, Chronic - metabolism
Hepatitis, Autoimmune - metabolism
Hepatitis, Chronic - metabolism
Humans
intercellular adhesion molecule 1
Intercellular Adhesion Molecule-1 - blood
Intercellular Adhesion Molecule-1 - metabolism
Liver Cirrhosis, Alcoholic - metabolism
Liver Cirrhosis, Biliary - metabolism
Liver Diseases - etiology
Liver Diseases - immunology
Male
Middle Aged
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Summary:Abstract The release of soluble circulating molecules represents a prominent feature during the course of immune-mediated clinical conditions. To further assess the relationship between serum concentrations of adhesion or apoptotic-related soluble structures and liver diseases, we evaluated the levels of intercellular adhesion molecule-1 (sICAM-1), Fas receptor (CD95) and Fas ligand (sCD95L) in a group of patients affected by Hepatitis C Virus (HCV)induced chronic hepatitis (CH-C), HCV-positive liver cirrhosis with superimposed hepatocellular carcinoma (HCC), autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and alcoholic liver cirrhosis (ALC). Results show that sICAM-1 values were in all instances significantly elevated when compared to those seen in healthy donors. Similar findings were noted in subjects with liver diseases in terms of sCD95 concentrations, even if to a different degree of statistical significance. Finally, sCD95L amounts were augmented in AIH, PBC, ALC and CH-C in comparison to controls, while in the HCC counterpart sCD95L levels fell within normal range. All together, these findings emphasize the occurrence of circulating soluble molecules in patients with various chronic liver diseases, likely reflecting the involvement of several pathogenetic mechanisms.
ISSN:0892-3973
1532-2513
DOI:10.3109/08923970009016403