Formaldehyde exposure alters miRNA expression profiles in the olfactory bulb

It has been reported that inhaling formaldehyde (FA) causes damage to the central nervous system. However, it is unclear whether FA can disturb the function of the olfactory bulb. Using a microarray, we found that FA inhalation altered the miRNA expression profile. Functional enrichment analysis of...

Full description

Saved in:
Bibliographic Details
Published in:Inhalation toxicology 2015-07, Vol.27 (8), p.387-393
Main Authors: Li, Guifa, Yang, Jing, Ling, Shucai
Format: Article
Language:English
Subjects:
Administration, Inhalation
Animals
Formaldehyde
Formaldehyde - adverse effects
Formaldehyde - toxicity
Male
Mice
Mice, Inbred ICR
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
olfactory bulb
Olfactory Bulb - drug effects
Oligonucleotide Array Sequence Analysis
Respiratory Hypersensitivity - chemically induced
Respiratory Hypersensitivity - pathology
Transcriptome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It has been reported that inhaling formaldehyde (FA) causes damage to the central nervous system. However, it is unclear whether FA can disturb the function of the olfactory bulb. Using a microarray, we found that FA inhalation altered the miRNA expression profile. Functional enrichment analysis of the predicted targets of the changed miRNA showed that the enrichment canonical pathways and networks associated with cancer and transcriptional regulation. FA exposure disrupts miRNA expression profiles within the olfactory bulb.
ISSN:0895-8378
1091-7691
DOI:10.3109/08958378.2015.1062580