The footprint of TGF-β in airway remodeling of the mustard lung

Mustard lung is a major pulmonary complication in individuals exposed to sulfur mustard (SM) gas during the Iran-Iraq war. It shares common pathological and clinical features with some chronic inflammatory lung disorders, particularly chronic obstructive pulmonary disease (COPD). Airway remodeling,...

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Bibliographic Details
Published in:Inhalation toxicology 2015-12, Vol.27 (14), p.745-753
Main Authors: Shahriary, Alireza, Seyedzadeh, Mir Hadi, Ahmadi, Ali, Salimian, Jafar
Format: Article
Language:English
Subjects:
Airway remodeling
Airway Remodeling - drug effects
COPD
Gene Expression Regulation - drug effects
Humans
Lung - metabolism
Lung - pathology
Lung Diseases - chemically induced
Mustard Gas - toxicity
sulfur mustard
TGF-β
Transforming Growth Factor beta - genetics
Transforming Growth Factor beta - metabolism
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Summary:Mustard lung is a major pulmonary complication in individuals exposed to sulfur mustard (SM) gas during the Iran-Iraq war. It shares common pathological and clinical features with some chronic inflammatory lung disorders, particularly chronic obstructive pulmonary disease (COPD). Airway remodeling, which is one of the main causes of lung dysfunction and the dominant phenomenon of chronic pulmonary diseases, is seen in the mustard lung. Among all mediators involved in the remodeling process, the transforming growth factor (TGF)-β plays a pivotal role in lung fibrosis and consequently in the airway remodeling. Regarding the high levels of this mediator detected in mustard lung patients, in the present study, we have discussed the possible roles of TGF-β in airway remodeling (including epithelial layer damage, subepithelial fibrosis and angiogenesis). Finally, based on TGF-β targeting, we have reviewed new airway remodeling therapeutic approaches.
ISSN:0895-8378
1091-7691
DOI:10.3109/08958378.2015.1116645