Clinical Features of Systemic Metastatic Retinal Lymphoma in Japanese Patients

Purpose: Systemic metastatic retinal lymphoma (SMRL) originates in systemic organs. It has been reported to exhibit clinical features similar to those of primary vitreoretinal lymphoma (PVRL). We report six cases of SMRL in a single-center survey in Japan. Methods: The clinical and pathologic featur...

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Bibliographic Details
Published in:Ocular immunology and inflammation 2017-09, Vol.25 (5), p.659-667
Main Authors: Taki, Rumiko, Takeda, Atsunobu, Yoshikawa, Hiroshi, Fukuhara, Takako, Arita, Ryoichi, Suehiro, Yoko, Choi, Ilseung, Kumano, Yuji, Nakamura, Takao, Ishibashi, Tatsuro
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Asian Continental Ancestry Group - ethnology
Breast Neoplasms - pathology
Clinical features
CNS involvement
Female
Gene Rearrangement
Humans
Immunoglobulin Heavy Chains - genetics
Intestinal Neoplasms - pathology
Japan - epidemiology
Lymphatic Metastasis
Lymphoma, Large B-Cell, Diffuse - diagnosis
Lymphoma, Large B-Cell, Diffuse - ethnology
Lymphoma, Large B-Cell, Diffuse - metabolism
Male
Neoplasm Proteins - metabolism
Paranasal Sinus Neoplasms - pathology
Polymerase Chain Reaction
primary organs
Retinal Neoplasms - diagnosis
Retinal Neoplasms - ethnology
Retinal Neoplasms - metabolism
Retrospective Studies
single-center study
Testicular Neoplasms - pathology
Thoracic Neoplasms - pathology
Vitrectomy
vitreoretinal lymphoma
Vitreous Body - pathology
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Summary:Purpose: Systemic metastatic retinal lymphoma (SMRL) originates in systemic organs. It has been reported to exhibit clinical features similar to those of primary vitreoretinal lymphoma (PVRL). We report six cases of SMRL in a single-center survey in Japan. Methods: The clinical and pathologic features in SMRL at the Kyushu University Hospital were retrospectively studied. Results: The mean patient age at the onset of ocular involvement was 75.3 years. Four patients had brain involvement. The primary sites were: breast (2); chest (1); testis (1); intestinal tract (1); and nasal sinus (1). In all patients, the cytology of vitreous samples indicated diffuse large B-cell lymphoma (DLBCL). Conclusions: DLBCL is the most common subtype in our study. The prevalence of CNS involvement in patients with SMRL is similar to that with PVRL. The testis and breast may be common sites of origin for SMRL.
ISSN:0927-3948
1744-5078
DOI:10.3109/09273948.2016.1151894