The efficacy of melatonin administration on oocyte quality

The aim of the study was to evaluate the efficacy of melatonin administration on oocyte quality in women underwent in vitro fertilization (IVF) cycles. Eighty-five women undergoing IVF cycles were randomized in two groups during IVF-embryo transfer (ET) procedure, 40 women with melatonin treatment (...

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Bibliographic Details
Published in:Gynecological endocrinology 2012-02, Vol.28 (2), p.91-93
Main Authors: Bat o lu, A. Sertaç, ahin, U ra, Gürlek, Beril, Öztürk, Nazire, Ünsal, Evrim
Format: Article
Language:English
Subjects:
Adult
Assisted reproductive technology
Embryo Transfer
Female
Fertilization in Vitro
Free Radical Scavengers - administration & dosage
Humans
melatonin
Melatonin - administration & dosage
Oocytes - drug effects
ovulation induction
Oxidative Stress
Pregnancy
Pregnancy Rate
Young Adult
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Summary:The aim of the study was to evaluate the efficacy of melatonin administration on oocyte quality in women underwent in vitro fertilization (IVF) cycles. Eighty-five women undergoing IVF cycles were randomized in two groups during IVF-embryo transfer (ET) procedure, 40 women with melatonin treatment (A) and 45 women without melatonin treatment (B). Primary endpoint was the number of morphologically mature oocytes retrieved (MII oocytes). Secondary endpoints were fertilization rate per number of mature oocytes, embryo quality and pregnancy rate. There were no differences between two groups according to age, and peak estradiol levels. The mean number of oocytes (15.33 vs. 14.27) and the mean number of mature oocytes did not differ between the two groups (12.63 vs. 10.94), whereas the percentage of mature oocytes (M2/oocytes retrieved) was significantly different in melatonin-treated group (p 
ISSN:0951-3590
1473-0766
DOI:10.3109/09513590.2011.589925