Pro12Ala PPAR γ2 gene polymorphism in PCOS women: the role of compounds regulating satiety

Five to ten percent of women of reproductive age suffer from polycystic ovary syndrome (PCOS). Leptin, NPY, galanin, cholecystokinin (CCK) are involved in the regulation of eating behavior. PPARγ are receptors that are probably involved in hyperandrogenism. This study was designed to assess associat...

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Bibliographic Details
Published in:Gynecological endocrinology 2012-03, Vol.28 (3), p.195-198
Main Authors: Bidzi ska-Speichert, Bo ena, Lenarcik, Agnieszka, Tworowska-Bardzi ska, Urszula, l zak, Ryszard, Bednarek-Tupikowska, Gra yna, Milewicz, Andrzej
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
CCK
Cholecystokinin - blood
Female
galanin
Galanin - blood
Genotype
Humans
Hyperandrogenism - blood
Hyperandrogenism - complications
Hyperandrogenism - genetics
Insulin Resistance - genetics
leptin
Leptin - blood
Neuropeptide Y - blood
NPY
Obesity - blood
Obesity - complications
Obesity - genetics
PCOS
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - genetics
Polymorphism, Genetic - genetics
PPAR gamma - genetics
Pro12Ala PPARγ2 polymorphism
Satiation - physiology
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Summary:Five to ten percent of women of reproductive age suffer from polycystic ovary syndrome (PCOS). Leptin, NPY, galanin, cholecystokinin (CCK) are involved in the regulation of eating behavior. PPARγ are receptors that are probably involved in hyperandrogenism. This study was designed to assess associations between the Pro12Ala PPARγ2 gene polymorphism and satiety factors in PCOS. Fifty-four PCOS women and 51 healthy women were studied. Leptin, NPY, galanin, CCK levels, and genetic studies to detect Pro12Ala PPARγ2 gene polymorphism were assessed. The leptin levels in the PCOS women carrying Pro12Ala genotype were higher than in those with Pro12Pro and Ala12Ala. The PCOS women had higher leptin and NPY levels and lower galanin levels. Obese PCOS patients had lower CCK levels. Conclusions: In the PCOS women, a single Ala allele may have a protective role as far as hyperleptinemia is concerned. The PCOS women may reveal a disrupted central leptin/NPY feedback loop with some shifts in food intake.
ISSN:0951-3590
1473-0766
DOI:10.3109/09513590.2011.593670